2,5-bis-O-{3-[amino(imino)methyl]phenyl}-1,4:3,6-dianhydro-D-glucitol

This compound is a synthetic small molecule belonging to the isosorbide class and structurally classified as a furofuran derivative. It features two phenylguanidine (amidino) groups attached to an isosorbide core. The molecule has been studied primarily as an experimental ligand for cationic trypsin (TRY1_BOVIN), where it acts as an inhibitor with a reported Ki of approximately 1190 nM. Its main research application has been in structural biology and enzymology studies involving serine proteases such as trypsin[2][6]. There are no known approved therapeutic indications or clinical uses for this compound.

Other names

1,4:3,6-dianhydro-2,5-bis-O-(3-carbamimidoylphenyl)-D-glucitol2,5-bis-O-(3-(amino(imino)methyl)phenyl)-1,4:3,6-dianhydro-D-glucitol3-{[(3R,3aR,6S,6aR)-6-(3-carbamimidoylphenoxy)-hexahydrofuro[3,2-b]furan-3-yl]oxy}benzene-1-carboximidamide