2',3'-dideoxycytidine-5'-monophosphate

**2',3'-Dideoxycytidine‐5'‐monophosphate (ddCMP)** is a synthetic nucleoside analog belonging to the class of pyrimidones. Structurally derived from cytidine by removal of the hydroxyl groups at the 2' and 3' positions and phosphorylation at the 5' position, ddCMP acts as an antiviral agent primarily studied for its activity against retroviruses such as HIV. Its mechanism involves incorporation into viral DNA or RNA by viral polymerases; once incorporated, it functions as a chain terminator due to its lack of a necessary hydroxyl group for further elongation. This halts viral genome synthesis and inhibits replication[1][2][3]. It is considered experimental and not approved for clinical use.

Other names

[(2S,5R)-5-(4-amino-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl]methoxyphosphonic acidpyrimidine 2'-deoxyribonucleoside 5'-monophosphatedeoxycytidine phosphatecytidine 5′-(trihydrogen monophosphate), 2′,3′‐dideoxy-