2',3'-dideoxythymidine-5'-monophosphate

**Description:** 2',3'-Dideoxythymidine‑5'‑monophosphate (ddTMP) is a synthetic pyrimidine nucleotide analog in which the ribose moiety lacks hydroxyl groups at both the 2' and 3' positions. It is structurally related to thymidine monophosphate but differs by these missing hydroxyls. This modification prevents further chain elongation when incorporated into DNA or RNA by polymerases. **Mechanism of Action:** ddTMP acts as a chain terminator during nucleic acid synthesis because its incorporation into DNA or RNA precludes the addition of subsequent nucleotides due to the absence of critical hydroxyl groups required for phosphodiester bond formation. It has been studied primarily as an investigative tool and potential antiviral agent targeting viral polymerases and kinases such as Mycobacterium thymidine monophosphate kinase[8]. Its main use is experimental; it is not approved for clinical use.

Other names

5'-Thymidylic acid, 3'-deoxy-(((2S,5R)-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl)methoxy)phosphonic acid{[(2S,5R)-5-(5-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)oxolan-2-yl]methoxy}phosphonic acid[(2S,5R)-5-(5-methyl–2,4-dioxo–3H-pyrimidin–1–yl)oxolan–2–yl]methoxyphosphonic aciddeoxy-thymidine monophosphate