2',5'-dideoxy-adenosine 3'-monophosphate

**Description:**\n2',5'-Dideoxy-Adenosine 3'-Monophosphate is a synthetic nucleoside monophosphate analog of adenosine. It belongs to the class of ribonucleoside phosphates and is characterized by the absence of hydroxyl groups at the ribose positions C'₂ and C'₅. This compound has been primarily used as an experimental tool in biochemical research rather than as a therapeutic agent. Its main mechanism involves acting as an inhibitor of adenylyl cyclase (also known as adenylate cyclase), thereby reducing cellular cyclic AMP (cAMP) levels. By mimicking natural nucleotides but lacking key functional groups required for enzymatic activity or further phosphorylation/elongation in nucleic acids or signaling pathways, it serves to block cAMP-mediated signal transduction[1][7]. There are no approved clinical indications for this molecule; it is classified as an experimental small molecule[1][3].

Other names

2',5'-DIDEOXYADENOSINE 3'-MONOPHOSPHATE2',5'-dideoxyadenosine 3’-monophosphate(((2R,3S,5R)-5-(6-amino-9H-purin-9‑yl)-2-methyloxolan‑3‑yl)oxy)phosphonic acid{[(2R,3S,5R)-5-(6-amino‑9H-purin‑9‑yl)-2-methyloxolan‑3‑yl]oxy}phosphonic acid[(2R,3S,5R)-5-(6-amino­purin–9–yl)–2-methyloxolan–3–yl] dihydrogen phosphate121878‐11‐32’,5’-dideoxyadenosine 3’-phosphoric acid[(2R,3S,5R)-5-(6-amino­purin–9–yl)–2-methyloxolan–3–yl] oxyphosphonic acid