2'-C-methylcytidine

2'-C-methylcytidine is a synthetic nucleoside analog with broad-spectrum antiviral activity, primarily investigated for its effects against hepatitis C virus (HCV), norovirus, and dengue virus. After cellular uptake, it is phosphorylated to its active triphosphate form, which acts as a chain terminator by inhibiting viral RNA-dependent RNA polymerase (notably the HCV NS5B polymerase). This inhibition blocks viral RNA synthesis and replication. It was the first nucleoside inhibitor of HCV NS5B polymerase shown to reduce viral load in patients with HCV infection. The compound has also demonstrated efficacy in preclinical models against norovirus and dengue virus[1][3][4][5][7].

Other names

2'-C-MecytosinCytidine, 2'-C-methyl-(+)-2'-C-Methylcytidine2CMCCS-2055CS2055CS 2055