2'-fluoro-2'-deoxyuridine 3'-monophosphate

**Description:** 2'-fluoro‑2'-deoxyuridine 3′‑monophosphate is a synthetic nucleoside monophosphate analog of deoxyuridine in which the hydrogen at the ribose sugar's C‑position is replaced by fluorine. It belongs to the class of pyrimidine antimetabolites and is structurally related to floxuridine (FUDR), a prodrug of fluorouracil. The compound acts as an inhibitor of thymidylate synthase by mimicking natural nucleotide substrates and interfering with DNA synthesis. This mechanism underlies its potential as an experimental antimetabolite for research into cancer therapeutics and possibly antimicrobial activity[1][7][8]. **Mechanism of Action:** - Inhibits thymidylate synthase by acting as a fraudulent nucleotide substrate. - Interferes with DNA synthesis through inhibition of dTMP production. - May be incorporated into nucleic acids or act as a precursor for further phosphorylated metabolites that disrupt cell proliferation[7][8].

Other names

1-(2-deoxy–fluoro–O-phosphono-beta-L-ribofuranosyl)pyrimidine–dione