2'-fucosyllactose + lactoneotetraose

**2'-fucosyllactose + lactoneotetraose** is a combination of two human milk oligosaccharides (HMOs): 2'-fucosyllactose (2'-FL), a neutral trisaccharide consisting of L-fucose, D-galactose, and D-glucose, and lactoneotetraose (more precisely, "lacto-N-neotetraose" or LNnT), a neutral tetrasaccharide consisting of D-galactose, N-acetyl-D-glucosamine, D-galactose, and D-glucose[1][3]. These oligosaccharides are naturally found in human breast milk and are among the most abundant HMOs present[1][3]. In infant formula, this combination is designed to mimic the composition and potential health benefits of breast milk for infants who cannot be breastfed. Mechanistically, 2'-FL and LNnT are indigestible by the upper gastrointestinal tract and reach the colon, where they serve as prebiotics—promoting the growth of beneficial gut bacteria such as bifidobacteria[3]. They also act as soluble decoy receptors, blocking the adhesion of pathogens to epithelial cells, thereby reducing infection risk[1][3]. Administration in infant formula has been shown to be safe and well tolerated in infants, with possible benefits for immune modulation (such as lower plasma inflammatory cytokine levels) and gut microbiota similar to that of breastfed infants[2][3]. This combination is not considered a pharmaceutical or conventional drug but rather a functional ingredient or dietary supplement, primarily regulated for use in infant foods[2][3][4].

Other names

2'-FL + LNnT2'-fucosyllactose + lacto-N-neotetraose