2'-hydroxyflavanone

2'-hydroxyflavanone is a naturally occurring flavanone, a type of flavonoid, with the chemical formula C15H12O3 and a molecular weight of 240.25 g/mol[1][3][5][6]. It exhibits various biological activities, including antiproliferative, anti-angiogenic, prodifferentiation, and anti-inflammatory properties. It has demonstrated the ability to inhibit cancer cell proliferation, induce apoptosis, reduce inflammation, and inhibit platelet aggregation[1][5]. In preclinical models, 2'-hydroxyflavanone has shown promising effects against various cancers and infectious diseases such as leishmaniasis, with studies reporting reduction in lesion size and parasite load in mice[4]. Mechanisms of action include inhibition of cancer cell growth and apoptosis induction, as well as inhibition of platelet function (via blocking aggregation induced by arachidonic acid and adenosine diphosphate).

Other names

2'-hydroxyflava2'-OH flavanone2-hydroxyflavanone2'-hydroxyflavononehydroxyflavanone 2'2-(2-hydroxyphenyl)chroman-4-one