Drug intelligence / Profile preview

2,5-O,O-bis-{4',4''-amidinophenyl}-1,4:3,6-dianhydro-D-sorbitol

Development stage
Unknown
Modality
Small Molecules
01

Overview

A synthetic small molecule belonging to the isosorbide class of organic compounds. It features two amidinophenyl groups attached to a dianhydro derivative of D-sorbitol. The compound has been referenced as a small molecule drug in chemical and biological databases but lacks evidence of clinical use or approval. Its mechanism of action is not well characterized in the literature; however it has been associated with interaction studies involving serine protease targets such as PRSS1 (trypsinogen). There are no known approved indications or marketed products containing this compound[1][2][7].

Other names
2,5-O,O-BIS-(4',4''-AMIDINOPHENYL)-1,4:3,6-DIANHYDRO-D-SORBITOL2,5-BIS-O-{4-[AMINO(IMINO)METHYL]PHENYL}-1,4:3,6-DIANHYDRO-D-GLUCITOL4-{[(3S,3aR,6R,6aR)-6-(4-carbamimidoylphenoxy)-hexahydrofuro[3,2-b]furan-3-yl]oxy}benzene-1-carboximidamide
02

Targets

PRSS1 (Trypsin family)

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