Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
2-((9H-purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound, commonly known as PIK‑39, is an experimental small molecule inhibitor of phosphatidylinositol 4,5-bisphosphate 3‑kinase delta (PIK3CD/PI3Kδ). It is a synthetic quinazoline derivative with a purine moiety and has been studied primarily as a research tool for dissecting PI3K signaling pathways. The drug exhibits potent inhibitory activity against the PI3Kδ isoform (IC50 ~180 nM), which plays a key role in immune cell function and cancer cell survival. There are no approved therapeutic indications or marketed formulations for this compound; it is used mainly in preclinical studies to investigate PI3K biology[1][4].
- Other names
- 5-chloro-3-(2-methoxyphenyl)-2-(9H-purin-6-yltio)methylquinazolinone5-chloro-3-(2-methoxyphenyl)-2-[1H-purin–6–ylsulfanyl]methyl–4(3H)–quinazolinoneDB06831DB-06831DB 06831
02
Targets
PIK3CD (Phosphatidylinositol 3-kinase delta)
Beyond the preview
Go deeper on 2-((9H-purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on 2-((9H-purin-6-ylthio)methyl)-5-chloro-3-(2-methoxyphenyl)quinazolin-4(3H)-one.