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2-(3-fluoropropyl)-DL-tryptophan

Development stage: Preclinical
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

2-FPTRP is a **fluorine-18 labeled tryptophan analog** developed as a positron emission tomography (PET) radiotracer for tumor imaging. It is a synthetic amino acid derivative, specifically 2-(3-fluoropropyl)-DL-tryptophan, designed for efficient tumor imaging. The compound acts as a substrate for amino acid transporters, primarily entering cells through **large neutral amino acid transporters (LAT)**. In vitro and in vivo studies show that it accumulates in tumor tissue, providing high tumor/background ratios in small animal PET imaging, making it potentially useful for the noninvasive imaging of tumors, especially in oncology research and diagnostics[3].

Other names: (18)F]2-FPTRP2-(3-[(18)F]fluoropropyl)-DL-tryptophan

Targets

SLC7A5 (Large neutral amino acid transporter small subunit 1)

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