2-(5-hydroxy-naphthalen-1-yl)-1,3-benzoxazol-6-ol

2-(5-hydroxy-naphthalen-1-yl)-1,3-benzoxazol‑6‑ol is an experimental small molecule belonging to the naphthol and benzoxazole chemical classes. It has demonstrated biological activity as a selective estrogen receptor modulator (SERM), with high affinity for both human estrogen receptor beta (ERβ) and alpha (ERα). In vitro studies show potent inhibition of ERβ (IC50 ≈ 5 nM) and moderate inhibition of ERα (IC50 ≈ 117 nM), suggesting potential utility in modulating estrogenic pathways. The compound has not been approved for any indication and remains at the experimental stage[1][8]. No clinical trials or marketed formulations are reported.

Other names

2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL2-(5-Hydroxy-naphthalen-1-yl)-benzooxazol-6-ol2-(5-hydroxynaphthalen-1-yl)benzo[d]oxazol-6-ol