2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4-amine

2-(6-methylpyridin-2-yl)-N-pyridin-4-ylquinazolin-4‑amine is an experimental small molecule belonging to the quinazoline class, specifically a pyridinyl-substituted quinazoline derivative. It has been studied as a kinase inhibitor, with notable activity against TGF-beta receptor type I (TGFBR1/ALK5), showing nanomolar affinity in biochemical assays. The compound also exhibits weaker inhibitory activity against p38alpha MAP kinase. Its primary mechanism of action is inhibition of TGF-beta signaling via ALK5 blockade, which may have potential therapeutic implications in fibrotic diseases and cancer; however, it has not advanced beyond preclinical or early experimental stages and is not approved for any indication[1][7][9].

Other names

2-(6-methylpyridin-2-yl)-N-(pyridin-4-yl)quinazolin-4-amine733806–89–8