Drug intelligence / Profile preview

2-(oxalyl-amino)-benzoic acid

Development stage
Preclinical
Lead developer
Novo Nordisk
Modality
Small Molecules
01

Overview

**Description:** 2-(Oxalyl-amino)-benzoic acid is a small molecule compound belonging to the class of acylaminobenzoic acids. It is functionally related to anthranilic acid and has been primarily studied as a general, reversible, competitive inhibitor of protein tyrosine phosphatases (PTPs). The compound binds to the active site of PTPs, mimicking the natural substrate and forming hydrogen bonds with key residues in the enzyme's signature motif. This mechanism makes it an important scaffold for developing selective PTP inhibitors, which are considered potential therapeutic agents for diseases such as diabetes, cancer, and inflammation. However, as of now it is classified as an experimental or discovery agent without approved clinical indications[1][3][4].

Other names
2-(oxaloamino)benzoic acid2-(OXALYL-AMINO)-BENZOIC ACID2-[(carboxycarbonyl)amino]benzoic acidOBA2-oxaloaminobenzoic acidAC1L9GUOAC-1L9GUOAC 1L9GUOSCHEMBL4315667SCHEMBL-4315667SCHEMBL 43156672-(Carboxyformamido)Benzoic AcidZINC2007905ZINC-2007905ZINC 2007905BDBM50118789BDBM-50118789BDBM 50118789AKOS022649621AKOS-022649621AKOS 022649621SC–575085651–01–4
02

Targets

PTPN1 (Protein tyrosine phosphatase 1B)

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