2-(Pyrido[1,2-E]Purin-4-Yl)Amino-Ethanol

2-(Pyrido[1,2-E]Purin-4-Yl)Amino-Ethanol is a synthetic purine derivative and experimental small molecule with potential antitumor activity. Its structure allows it to intercalate between CpG dinucleotide steps in DNA duplexes, with its side chain lying in the minor groove. The drug forms weak stacking interactions with DNA bases and establishes hydrogen bonds that enhance its affinity for DNA. This mechanism suggests it acts as a DNA intercalator, disrupting normal DNA function and potentially inhibiting cancer cell proliferation. It has been studied as a new antineoplastic agent but has not advanced beyond preclinical or early research stages[1][3][4][7].

Other names

2-(purino[9,8-a]pyridin-4-ylamino)ethanolPPZ (ligand code)DB01994 (DrugBank ID)