2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethanol

This compound is an experimental small molecule belonging to the class of organic compounds known as 2,3-diphenylfurans. It has a molecular formula of C20H17N3O2 and a molecular weight of approximately 331.37 g/mol. The compound has been studied as an inhibitor of serine/threonine-protein kinase Chk1 (checkpoint kinase 1), which plays a key role in cell cycle regulation and DNA damage response pathways. There are no approved indications or clinical trials beyond preclinical/experimental studies for this molecule. Its mechanism involves binding to Chk1 with moderate affinity (IC50 ~20.9 μM), potentially interfering with cell cycle progression and DNA repair processes by inhibiting Chk1 activity[1][3][6].

Other names

2-(5,6-Diphenyl-furo[2,3-d]pyrimidin-4-ylamino)-ethanol2-(5,6-Diphenylfuro[2,3-d]pyrimidin-4-ylamino)ethanolEthanol, 2-[5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]