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2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1R)-1-(hydroxymethyl)propyl]acetamide
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the benzoylindole class, structurally related to indomethacin derivatives. It features an indole core substituted with a chlorobenzoyl group and additional methoxy and methyl groups, as well as an acetamide side chain with a chiral (R) hydroxymethylpropyl substituent. The compound is experimental and has been studied primarily in research settings. Its mechanism of action is presumed to involve inhibition of prostaglandin G/H synthase enzymes (COX enzymes), similar to other indomethacin analogs, but specific pharmacological data are limited. There are no known approved therapeutic indications or marketed products containing this molecule[3][4].
- Other names
- 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[(2R)-1-hydroxybutan-2-yl]acetamide2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-{(S)-[hydroxymethyl]propyl}acetamideα-substituted indomethacin ethanolamide, 8
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)
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