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2-[1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]-n-[(1S)-1-(hydroxymethyl)propyl]acetamide

Development stage
Unknown
Modality
Small Molecules
01

Overview

This compound is a synthetic small molecule belonging to the benzoylindole class, structurally related to indomethacin derivatives. It features an indole core substituted with a 4-chlorobenzoyl group, a methoxy group at position 5, and a methyl group at position 2. The acetamide side chain is N-substituted with a (S)-configured hydroxymethylpropyl moiety. The compound has been referenced in chemical databases as an experimental or research molecule but does not have established clinical use or well-documented pharmacological activity in humans. Its mechanism of action is not explicitly described in public sources; however, by analogy to related indomethacin derivatives, it may act as an inhibitor of prostaglandin G/H synthase (cyclooxygenase), though this specific activity for this exact derivative has not been confirmed[6][4].

Other names
2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]-N-[(2R)-1-hydroxybutan-2-yl]acetamideIUPAC: 2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol‑3‑yl]‑N‑[(2R)‑1‑hydroxybutan‑2‑yl]acetamide
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)

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