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2-[18F]fluoroethyl-L-phenylalanine
- Development stage
- Unknown
- Lead developer
- Ghent University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
2-[18F]fluoroethyl-L-phenylalanine (also known as 2-[18F]FELP) is a novel radiofluorinated L-type amino acid transporter 1 (LAT1)-specific positron emission tomography (PET) imaging tracer developed by Ghent University and Ghent University Hospital. It is designed for brain tumor imaging, specifically to differentiate glioblastoma from radiation necrosis and neuroinflammation, which is a major clinical challenge with conventional tracers like [18F]FDG. 2-[18F]FELP is transported into cells via LAT1, which is highly overexpressed in glioblastoma cells but has low expression in normal brain tissue and inflammatory cells. It is currently in Phase I clinical development for glioblastoma imaging.
- Other names
- (S)-2-[18F]FELP18F-FELP2-[18F]-2-fluoroethyl-L-phenylalanine2-[18F]FELP2-[18F]fluoroethyl-l-phenylalanine[18F]FELP
02
Targets
SLC7A5 (Large neutral amino acid transporter small subunit 1)
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