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2-{(9as)-9a-[(1s)-1-Hydroxyethyl]-2,7-Dimethyl-9a,10-Dihydro-5h-Pyrimido[4,5-d][1,3]thiazolo[3,2-a]pyrimidin-8-yl}ethyl trihydrogen diphosphate

Development stage
Unknown
Modality
Small Molecules
01

Overview

This compound is a synthetic small molecule belonging to the class of organic pyrophosphates and is known as an experimental drug with no established clinical use in humans. It has been studied primarily as a ligand or inhibitor for biochemical research purposes rather than as a therapeutic agent. Its main identified biological target is acetolactate synthase (catabolic), specifically from the bacterium Klebsiella pneumoniae; however, its pharmacological action in humans remains unknown and it does not have an approved medical indication[2][6]. The compound's structure features a pyrimido-thiazolo-pyrimidine core with ethyl trihydrogen diphosphate substitution.

Other names
2-hydroxyethyl dihydrothiachrome diphosphate((hydroxy((2-((3S)-3-((1S)-1-hydroxyethyl)-6,12-dimethyl-4-thia-2,7,11,13-tetraazatricyclo(7.4.0.03)trideca-1(13),5,9,11-tetraen-5-yl)ethoxy))phosphoryl)oxy)phosphonic acid{[hydroxy({2-[ (3S ) - 3 - [ ( 1S ) - 1-hydroxyethyl ] -6 ,12-dimethyl -4-thia -2 ,7 ,11 ,13-tetraazatricyclo [7 .4 .0 .03 ]trideca -1 (13 ),5 ,9 ,11-tetraen -5-y l]ethoxy }) phosphoryl ] oxy } phosphonic acid
02

Targets

AHAS (Acetolactate synthase)

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