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2-{[4-(2-Acetylamino-2-pentylcarbamoyl-ethyl)-naphthalen-1-YL]-oxalyl-amino}-benzoic acid

Development stage
Unknown
Modality
Small Molecules
01

Overview

This compound is a synthetic small molecule belonging to the class of acylaminobenzoic acids and derivatives. It is known as an experimental inhibitor of protein tyrosine phosphatase, non-receptor type 1 (PTPN1 or PTP1B), a key negative regulator of insulin and leptin signaling pathways. By inhibiting PTPN1, this molecule has been investigated for its potential in modulating metabolic disorders such as diabetes and obesity, though it has not advanced to clinical development or approval[10][5][8]. The compound is referenced in chemical databases under CHEMBL1230658 and DrugBank DB01820.

Other names
2-(1-carboxy-N-(4-((2S)-2-acetamido-2-(pentylcarbamoyl)ethyl)naphthalen-1-yl)formamido)benzoic acid2-[{4-[2-Acetamido-3-oxo-3-(pentylamino)propyl]-1-naphthyl}(carboxycarbonyl)amino]benzoic acid
02

Targets

PTPN1 (Protein tyrosine phosphatase 1B)

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