2-{3-[4-(4-fluorophenyl)-3,6-dihydro-1(2h)-pyridinyl]propyl}-8-methyl-4(3h)-quinazolinone

This compound is a synthetic small molecule belonging to the class of quinazolines. Its structure features a quinazolinone core substituted with an 8-methyl group and a propyl chain linked to a dihydropyridine ring bearing a para-fluorophenyl substituent. It has been studied as an experimental agent and is known to act as an inhibitor of poly [ADP-ribose] polymerase 1 (PARP1), with reported IC50 values in the low nanomolar range. PARP inhibitors are being explored for their potential in cancer therapy due to their role in DNA repair inhibition[2][4]. There is no evidence that this compound has reached clinical development or approval.

Other names

2-{3-[4-(4-Fluorophenyl)-3,6-Dihydro-1(2h)-Pyridinyl]Propyl}-8-Methyl-4(3h)-Quinazolinone2-{3-[4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-1-yl]propyl}-8-methyl-3,4-dihydroquinazolin-4-onequinazolinone analogue 1e