2-methylthioadenosine 5'-diphosphate

2-methylthioadenosine 5'-diphosphate (2Me-SADP) is a potent nucleotide analog that serves as an agonist for several P2Y purinergic receptors, most notably the P2Y1, P2Y12, and P2Y13 subtypes. It is widely utilized as a pharmacological research tool to investigate purinergic signaling pathways involved in platelet aggregation, neurotransmission, and vascular tone regulation. In experimental models of pulmonary hypertension, 2Me-SADP has been evaluated for its potential vasodilatory properties, although studies in rat arterial tissues have demonstrated relatively low maximal efficacy compared to other vasodilators like sildenafil or riociguat. It is primarily recognized as a high-affinity probe for characterizing the structure and function of ADP-binding purinoceptors.

Other names

2-(Methylthio)adenosine 5'-diphosphate2-methylthio-ADP