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2-oxo-2h-chromene-6-sulfonic acid (5-oxo-4,5-dihydro-1h-pyrazol-3-yl)amide
- Development stage
- Preclinical
- Lead developer
- National Research Centre
- Modality
- Small Molecules
01
Overview
2-oxo-2h-chromene-6-sulfonic acid (5-oxo-4,5-dihydro-1h-pyrazol-3-yl)amide is a synthetic sulfonyl coumarin derivative developed as a non-cytotoxic anti-angiogenic agent. Synthesized by researchers at the National Research Centre in Egypt, this small molecule is designed to target pathways involved in tumor angiogenesis. It demonstrates anti-migratory activity against hepatocellular carcinoma (HepG2) cells in vitro without inducing direct cytotoxicity. Molecular docking studies indicate that the compound binds to the active site of Matrix Metalloproteinase-2 (MMP-2), suggesting its potential as a lead compound for non-toxic cancer therapies that inhibit tumor vascularization and metastasis.
- Other names
- 2-oxo-2H-chromene-6-sulfonic acid (5-oxo-4,5-dihydro-1H-pyrazol-3-yl)amide
02
Targets
MMP2 (Matrix metalloproteinase-2)
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