24,25-dihydroxyvitamin D3

24,25-dihydroxyvitamin D3 (24,25(OH)2D3) is a naturally occurring metabolite of vitamin D3, synthesized from 25-hydroxyvitamin D3 by the enzyme CYP24A1. Historically viewed as an inactive catabolic byproduct of the vitamin D pathway, recent research has identified it as a biologically active signaling molecule with specific roles in bone and cartilage physiology. It has been shown to promote osteoblast differentiation and bone mineralization without the excessive bone resorption typically associated with high doses of 1,25-dihydroxyvitamin D3. Clinical and preclinical studies have investigated its potential as a therapeutic agent for conditions such as X-linked hypophosphatemic rickets, osteomalacia, and osteoarthritis, where it may improve bone lesions and protect articular cartilage. Additionally, it serves as a clinical biomarker for vitamin D catabolic status and the diagnosis of CYP24A1 mutations.

Other names

24,25-dihydroxycholecalciferol24,25-dihydroxyvitamin D24-hydroxycalcidiol24-hydroxycalcifediol