Drug intelligence / Profile preview

25-hydroxyvitamin D + menaquinone-7

Development stage
Unknown
Lead developer
NattoPharma
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination dietary supplement containing two active ingredients: 25-hydroxyvitamin D (commonly known as vitamin D3 or cholecalciferol) and menaquinone-7 (MK-7), a form of vitamin K2. The supplement is designed to address deficiencies in both vitamins, which play complementary roles in bone and cardiovascular health. Vitamin D3 enhances calcium absorption from the gut and supports bone mineralization, while MK-7 activates proteins involved in calcium transport and inhibits vascular calcification by promoting carboxylation of matrix Gla-protein. This combination is marketed for individuals with low levels of both vitamins to support bone strength and potentially reduce arterial calcification risk[1][2][5]. It is available over-the-counter as an oral supplement.

Brand names
Dosokap
Other names
vitamin D3 + menaquinone-7vitamin D3 + MK-7cholecalciferol + menaquinone-7vitamin D3 and K2 combination
02

Targets

GGCX (Vitamin K-dependent gamma-glutamyl carboxylase)VDR (Vitamin D receptor)

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