2s,4r-4-methylglutamate

**2s,4r-4-Methylglutamate** is a synthetic amino acid derivative and a structural analog of glutamic acid. It is characterized by its specific stereochemistry at the 2 and 4 positions. This compound acts as a highly selective and potent agonist for kainate-type ionotropic glutamate receptors in the central nervous system. At higher concentrations, it also selectively inhibits the excitatory amino acid transporter EAAT2. Due to these properties, it is primarily used as an experimental tool in neuroscience research to study excitatory neurotransmission and receptor pharmacology[5][3][7]. There are no approved therapeutic indications or clinical uses for this compound.

Other names

(2S,4R)-4-methylglutamic acid(2S,4R)-2-amino-4-methylpentanedioic acid(2R,4S)-4-amino-4-carboxy-2-methylbutanoate