3',5'-dibromo-2',4,4',6'-tetrahydroxy aurone

**3',5'-Dibromo-2',4,4',6'-tetrahydroxy aurone** is a synthetic small molecule belonging to the class of aurone flavonoids. Structurally it is an aurone substituted with hydroxy groups at positions 2’, 4, 4’, and 6’ and bromo groups at positions 3’ and 5’. It has been studied as a potent competitor for thyroid hormone binding to human transthyretin (TTR), a serum thyroid hormone transport protein. The compound binds in two distinct modes within the TTR channel and acts as an inhibitor of iodothyronine deiodinase. Its primary research interest lies in its ability to modulate TTR function and potentially disrupt thyroid hormone transport or metabolism[1][6][8]. There are no approved clinical indications or marketed formulations; it remains an experimental compound.

Other names

(Z)-3',5'-dibromo-2',4,4',6'-tetrahydroxyaurone3′,5′-Dibromo-2′,4,4′,6-tetrahydroxyaurone(2Z)-2-(3,5-dibromo-2,4-dihydroxybenzylidene)-4,6-dihydroxy-1-benzofuran-3(2H)-one105098‑41‑7 [CAS]