3'-deoxyguanosine

**3'-Deoxyguanosine** is a synthetic purine nucleoside analog in which the ribose sugar of guanosine lacks a hydroxyl group at the 3' position. It is classified as a member of the guanosines and purine nucleosides. This compound acts primarily as an inhibitor of RNA-directed RNA polymerase (EC 2.7.7.48), interfering with transcription processes[3][5][6]. It can also bind to and inhibit purine nucleoside phosphorylase[2][4], an enzyme involved in nucleotide metabolism. As such, it has been studied for its potential antitumor activity—mainly through inhibition of DNA synthesis and induction of apoptosis—and for possible antiviral or anti-infective effects due to its ability to impair viral replication[1][6]. Its use remains experimental; it is not approved for clinical use.

Other names

Guanosine, 3'-deoxy-9-(3-deoxy-beta-D-ribofuranosyl)guanineCHEBI:398742-amino-9-((2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-1H-purin-6-oneGuanine, 9-(3-deoxy-.beta.-D-erythro-pentofuranosyl)-