3'-fluoro-3'-deoxythymidine 5'-monophosphate

**Description:**\n3′‑Fluoro‑3′‑deoxythymidine 5′‑monophosphate is a synthetic nucleotide analogue of thymidine monophosphate in which the hydroxyl group at the ribose’s third carbon is replaced by fluorine. It belongs to the class of pyrimidone nucleotides and acts as an inhibitor or substrate for certain kinases such as Mycobacterium tuberculosis thymidylate kinase. The compound has been studied primarily as a biochemical tool and experimental agent; it was investigated in early-stage clinical trials (up to phase II) for antiviral applications but development was discontinued[1][2][4][7]. It is not approved for any therapeutic use.

Other names

3'-Fluoro-3'-deoxythymidine 5'-monophosphate3'-Deoxy-3'-fluorothymidine monophosphate3-Fluoro-3-deoxythymidine monophosphate5'-Thymidylic acid, 3'-deoxy-3'-fluoro-[(2R,3S,5R)-3-fluoro-5-(5-methyl–2,4-dioxopyrimidin–1–yl)oxolan–2–yl]methyl dihydrogen phosphateCAS:25520‑83‑6