3,4-methylenedioxyamphetamine

**3,4-methylenedioxyamphetamine (MDA), also known as tenamfetamine, is a synthetic entactogen, stimulant, and psychedelic drug of the amphetamine and MDxx chemical families. It acts primarily as a serotonin–norepinephrine–dopamine releasing agent (SNDRA) and as an agonist at the serotonin 5‑HT2A receptor. Its mechanism involves inhibiting the reuptake of catecholamines (dopamine and norepinephrine) and serotonin by acting as a substrate for their respective transporters—serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT)—resulting in increased synaptic concentrations of these neurotransmitters. MDA produces entactogenic effects such as enhanced empathy, sociability, euphoria, stimulation, mild psychedelic experiences, and anxiety suppression. It has been used experimentally to study neurotoxicity due to its potential to destroy serotonergic neurons at high doses. First synthesized in 1910 by G. Mannish and W. Jacobson, it is now classified internationally as a controlled substance due to its psychoactive properties and abuse potential[2][3][4][5][6][7].**

Brand names

Amphedoxamine

Other names

AmphedoxamineSallySassafrasSass-a-frassSassMellow Drug of AmericaLove