3'-deoxy-3'-aminothymidine monophosphate

**Description:** \n3'-deoxy‐3'-aminothymidine monophosphate is a synthetic nucleotide analog and phosphorylated derivative of thymidine. It features an amino group at the 3' position in place of the usual hydroxyl group and is phosphorylated at the 5' position. This compound belongs to the class of pyrimidones and has been studied as an experimental molecule with potential applications in antiviral therapy due to its structural similarity to natural nucleotides. Its mechanism likely involves incorporation into DNA or RNA chains by viral polymerases or interference with nucleic acid synthesis; however, it is not approved for clinical use and remains primarily a research tool[1][2]. \nThe compound has also been identified as a catabolite related to certain antiretroviral drugs (such as AZT), where it may contribute to cytotoxicity[9].

Other names

3'-Amino-3'-deoxythymidine 5'-monophosphate(((2S,3S,5R)-3-amino-5-(4-hydroxy-5-methyl-2-oxo-1,2-dihydropyrimidin-1-yl)oxolan-2-yl)methoxy)phosphonic acid{[(2S,3S,5R)-3-amino-5-(4-hydroxy–5-methyl–2–oxo–1,2-dihydropyrimidin–1–yl)oxolan–2–yl]methoxy}phosphonic acid42214‑32‑4Thymidine, 3′‑amino‑3′‑deoxy-, 5′-(dihydrogen phosphate)1-{(4S,5S,2R)-4-Amino‑5-[phosphonooxy)methyl]oxolan‑2‑yl}-5-methyl−1,3-dihydropyrimidine−2,4-dione