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3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule belonging to the quinazolinamine family. It features a pyridinone core with an indoline and an aminoquinazoline group. The drug has been studied as a kinase inhibitor with potent activity against vascular endothelial growth factor receptor 2 (VEGFR2), which is involved in angiogenesis and tumor growth. By inhibiting VEGFR2 signaling pathways—including MAPK and AKT—it may suppress cancer progression and metastasis. Its primary applications are experimental, focused on oncology research as an antiangiogenic agent[5][1][7].
- Other names
- 3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolinyl)-4-methylpyridinone1-(3,3-dimethylindolin-6-yl)-4-methylpyridinone
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)
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