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3-(3,5-dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonic acid [4-(thiazol-2-ylsulfamoyl)-phenyl]-amide
- Development stage
- Preclinical
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule inhibitor of protein tyrosine phosphatase 1B (PTP1B), an enzyme that negatively regulates insulin and leptin signaling. By inhibiting PTP1B, the drug is designed to enhance insulin sensitivity and has been investigated as a potential therapeutic agent for metabolic disorders such as type 2 diabetes and obesity. The molecule contains dibromohydroxybenzoyl and thiazolylsulfamoyl moieties linked via a benzofuran scaffold with sulfonic acid functionality. It is primarily used in research settings to study the role of PTP1B in cellular signaling pathways[1][5][7].
- Other names
- 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-{4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}-1-benzofuran-6-sulfonamide765317–72–43-(3,5-Dibromo–4-Hydroxy-Benzoyl)–2-Ethyl-Benzofuran–6-Sulfonic Acid (4-(Thiazol–2-Ylsulfamoyl)–Phenyl)–Amide
02
Targets
PTPN1 (Protein tyrosine phosphatase 1B)
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