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3-(4-carbamoyl-1-carboxy-2-methylsulfonyl-buta-1,3-dienylamino)-indolizine-2-carboxylic acid

Development stage: Preclinical
Modality: Small Molecules

Overview

This compound is a synthetic small molecule designed as an inhibitor of beta-lactamase enzymes. Beta-lactamases are bacterial enzymes that confer resistance to beta-lactam antibiotics (such as penicillins and cephalosporins) by hydrolyzing the antibiotic's beta-lactam ring. The compound acts by binding to and inhibiting the activity of class C (AmpC) serine beta-lactamases, thereby restoring or enhancing the efficacy of beta-lactam antibiotics against resistant bacteria. It has been studied structurally in complex with SHV-type and Enterobacter cloacae GC1 class C beta-lactamases[4][5][7]. The molecule is experimental and not approved for clinical use.

Other names: 3-(4-carbamoyl-1-carboxy-2-methylsulfonyl-buta-1,3-dienylamino)-indolizine-2-carboxylic acid

Targets

β-lactamase

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