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3-[(2,4-dichlorobenzoyl)(isopropyl)amino]-5-phenylthiophene-2-carboxylic acid

Development stage
Preclinical
Modality
Small Molecules
01

Overview

This compound is a synthetic small molecule with the chemical formula C21H17Cl2NO3S and a molecular weight of approximately 434.33 g/mol[1][3]. It belongs to the class of organic compounds known as halobenzoic acids and derivatives[2]. The molecule has been studied experimentally but is not approved for any medical use or indication. Computational studies have explored its potential as an inhibitor targeting the RNA-dependent RNA polymerase (RdRp) of SARS-CoV‑2 (COVID‑19), suggesting possible antiviral activity through binding at the GTP binding site of RdRp[6]. However, there are no clinical trials or regulatory approvals for this compound in any therapeutic area.

Other names
3-((2,4-dichlorobenzoyl)(isopropyl)amino)-5-phenylthiophene-2-carboxylic acid5-phenyl-3-(N-(propan-2-yl)2,4-dichlorobenzamido)thiophene-2-carboxylic acid5-phenyl-3-[N-(propan-2-isopropyl)2,4-dichlorobenzamido]thiophene‑2‑carboxylic acid
02

Targets

RdRp (Coronavirus RNA-dependent RNA polymerase)

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