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3-[[(methylamino)sulfonyl]amino]-2-oxo-6-phenyl-n-[3,3,3-trifluoro-1-(1-methylethyl)-2-oxophenyl]-1(2h)-pyridine acetamide

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
01

Overview

This compound is a synthetic small molecule belonging to the phenylpyridine class of organic compounds. It is structurally characterized by a pyridine core substituted with phenyl, trifluoromethyl, and methylaminosulfonyl groups. The compound has been cataloged in several chemical and drug databases (DrugBank DB08614, ChEMBL1236262) and is primarily referenced as an experimental or research ligand rather than a marketed pharmaceutical product. Its most notable biochemical activity is as a potent inhibitor of chymotrypsin-like elastase family member 1 (CELA1), with reported nanomolar affinity (Ki = 18 nM) in protein-ligand binding studies using porcine enzyme models[4]. There are no approved therapeutic indications or clinical development programs associated with this molecule.

Other names
DB08614DB-08614DB 08614TFKCHEMBL1236262CHEMBL-1236262CHEMBL 1236262PubChem CID 445290
02

Targets

PDE4 (Phosphodiesterase 4A1)

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