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3-{[(2,2-dioxido-1,3-dihydro-2-benzothien-5-yl)amino]methylene}-5-(1,3-oxazol-5-yl)-1,3-dihydro-2H-indol-2-one
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
This compound is a synthetic small molecule inhibitor known as LS3. It is an oxindole-based inhibitor with high selectivity for cyclin-dependent kinase 2 (CDK2) over other kinases and CDK family members. The selectivity is attributed to the presence of a sulfonyl group that interacts specifically with residues Asp86 or Lys89 in the CDK2 binding site. LS3 has been used in structural biology studies to elucidate kinase-inhibitor interactions but has not advanced into clinical development or received regulatory approval[6][4][10].
- Other names
- 5-(1,3-Oxazol-5-Yl)-1,3-Dihydro-2H-Indol-2-One5-{[(3Z)-5-(1,3-Oxazol-5-Yl)-2-Oxo–1H-Indol–3-Ylidene]Methyl}Amino–1,3-Dihydro–2λ⁶-Benzothiophene–2,2-Dione
02
Targets
CDK2 (Cyclin-dependent kinase 2)CDK1 (Cyclin-dependent kinase 1)
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