3-{[4-([amino(imino)methyl]aminosulfonyl)anilino]methylene}-2-oxo-2,3-dihydro-1H-indole

This compound is a synthetic small molecule belonging to the benzenesulfonamide class. It is an oxindole-based inhibitor that specifically targets cyclin-dependent kinase 2 (CDK2), a key regulator of cell cycle progression. The compound has been studied structurally in complex with CDK2 and functions as a transferase inhibitor by binding to the ATP-binding site of CDK2, thereby inhibiting its kinase activity. It has not been approved for clinical use and remains an experimental molecule primarily used in biochemical and structural studies related to cell cycle regulation and cancer research[1][5][10].

Other names

1-[4-({[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}amino)benzenesulfonyl]guanidineN-Carbamimidoyl-4-{[(Z)-(2-oxo–1,2-dihydro–3H-indol–3‑ylidene)methyl]amino}benzenesulfonamide