3-nitro-4-(2-oxo-pyrrolidin-1-yl)-benzenesulfonamide

**3-Nitro-4-(2-Oxo-Pyrrolidin-1-Yl)-Benzenesulfonamide** is a synthetic small molecule belonging to the phenylpyrrolidine class of organic compounds. It has the molecular formula C10H11N3O5S and a molecular weight of approximately 285.28 g/mol[1][8]. The compound is primarily studied as an experimental inhibitor of carbonic anhydrase enzymes, particularly carbonic anhydrase II, with high potency (IC50 ~0.62 nM)[4][8]. Carbonic anhydrases are zinc-containing enzymes involved in the reversible hydration of carbon dioxide and play roles in pH regulation and ion transport. Inhibition of these enzymes can be relevant for conditions such as glaucoma, epilepsy, edema, and some cancers; however, this compound has not been approved for any clinical use or indication[4]. Its main application remains in biochemical research as a tool compound for studying enzyme inhibition.

Other names

3-nitro-4-(2-oxopyrrolidinyl)benzenesulfonamide3-nitro-4-(2-oxo-pyrrolidinyl)benzene-sulfonamideBenzenesulfonamide, 3-nitro-4-(2‑oxo‑1-pyrrolidinyl)