Drug intelligence / Profile preview

3F8 + interleukin-2

Development stage: Unknown
Lead developer: Memorial Sloan Kettering Cancer Center
Modality: Cytokines & Interferons → Recombinant Proteins and Enzymes, Monoclonal Antibodies → Antibody-Based Therapeutics
Administration: Intravenous, Subcutaneous

Overview

3F8 + interleukin-2 is a combination immunotherapy approach for treating high-risk neuroblastoma. 3F8 is a murine IgG3 monoclonal antibody that specifically targets the ganglioside GD2, which is highly expressed on neuroblastoma cells but has restricted distribution in normal human tissues. The antibody works by binding to GD2, activating complement, and mediating antibody-dependent cell-mediated cytotoxicity (ADCC). Interleukin-2 is an immune system stimulant that enhances the activity of immune cells, particularly natural killer cells, potentially boosting the anti-tumor effects of 3F8. This combination aims to improve outcomes in patients with high-risk neuroblastoma.

Other names: m3F8 + interleukin-23F8 MAb + interleukin-2Murine 3F8 monoclonal antibody + interleukin-2

Targets

GD2IL-2R (Interleukin-2/interleukin-15 receptor complex)

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