4'-demethylepipodophyllotoxin

4'-demethylepipodophyllotoxin is a semi-synthetic derivative of podophyllotoxin and a critical intermediate in the production of the anticancer agents etoposide and teniposide. Developed by XinKe Pharmaceutical, this small molecule functions as a DNA topoisomerase II inhibitor. By stabilizing the transient complex between the enzyme and DNA, it prevents the religation of DNA strands, leading to double-strand breaks, cell cycle arrest in the S and G2 phases, and ultimately programmed cell death. It is primarily utilized as a precursor in the synthesis of more soluble and less toxic podophyllotoxin analogs for the treatment of various malignancies, though it is also listed within XinKe's pipeline for cancer applications.

Other names

4'-demethyl-epi-podophyllotoxinDMEP4'-O-demethylepipodophyllotoxin4'-demethylepipodophyllotoxin-XinKe