4'-fluoro-1,1'-biphenyl-4-carboxylic acid

A synthetic small molecule belonging to the biphenyl carboxylic acids class. It is primarily used as a research tool and chemical intermediate. The compound acts as an inhibitor of Bcl‑2-like protein 1 (Bcl-xL), a member of the Bcl‑2 family involved in regulating apoptosis. By binding to Bcl‑2-like protein 1 with moderate affinity (KD ~400 μM), it has been explored for its potential in developing selective anti-cancer agents targeting apoptotic pathways[1][8]. There are no approved medical indications or clinical trials for this compound.

Other names

4-(4-fluorophenyl)benzoic acid4-fluoro-biphenyl-4-carboxylic acid[1,1'-biphenyl]-4-carboxylic acid, 4'-fluoro-4-fluorobiphenyl-4-carboxylic acid5731-10-2