4-(aminosulfonyl)-N-[(4-fluorophenyl)methyl]-benzamide

4-(aminosulfonyl)-N-[(4-fluorophenyl)methyl]-benzamide is a synthetic small molecule belonging to the benzamide class, featuring a sulfonamide group and a para-substituted fluorobenzyl moiety. It is primarily studied as an experimental inhibitor of carbonic anhydrase II, an enzyme involved in the reversible hydration of carbon dioxide. The compound binds with high affinity to carbonic anhydrase II (CA2), acting as a competitive inhibitor at the active site, and has been used in structural biology studies to probe protein-ligand interactions and fluoroaromatic binding effects. There are no approved therapeutic indications or marketed formulations for this compound; it is used mainly in research settings[1][2][6].

Other names

N-(4-fluorobenzyl)-4-sulfamoylbenzamideN-(4-fluorophenyl)methyl)-4-sulfamoylbenzamideN-[4-fluorophenyl)methyl]-4-sulfamoylbenzamide