4-(carboxyvin-2-yl)phenylboronic acid

4-(Carboxyvin-2-Yl)Phenylboronic Acid is a synthetic small molecule containing both a boronic acid and carboxylic acid functional group, with the chemical formula C9H9BO4 and molecular weight of approximately 192 g/mol[1][2][5]. It is primarily studied as an experimental compound and has been used in structural biology as an inhibitor of beta-lactamase enzymes, such as AmpC beta-lactamase from Escherichia coli. The mechanism involves binding to the active site of the enzyme, mimicking transition states or intermediates in enzymatic reactions, thereby inhibiting its function[8][10]. This makes it relevant for research into overcoming bacterial resistance to beta-lactam antibiotics. There are no known approved therapeutic indications or marketed formulations for this compound.

Other names

(2E)-3-[4-(dihydroxyboranyl)phenyl]prop-2-enoic acid(E)-3-(4-boronophenyl)acrylic acid(2E)-3-(4-(dihydroxyboranyl)phenyl)prop-2-enoic acid