4-[(4-O-sulfamoylbenzyl)(4-cyanophenyl)amino]-4H-[1,2,4]-triazole

This compound is a synthetic small molecule with the chemical formula C16H14N6O3S and a molecular weight of approximately 370.39 g/mol. It is classified as an experimental drug and belongs to the phenylhydrazine class of organic compounds[2][3]. The structure features a triazole ring substituted with both a cyanophenyl group and an O-sulfamoylbenzyl moiety. Structural studies (e.g., PDB entry 1xpz) show that it binds to human carbonic anhydrase II[10], suggesting its function as a carbonic anhydrase inhibitor. Additionally, literature and database annotations indicate activity as both an aromatase inhibitor and steroid sulfatase (STS) inhibitor—making it part of the dual aromatase–sulfatase inhibitor (DASI) class[3]. These mechanisms are relevant for potential antineoplastic or endocrine-related therapeutic applications; however, there are no approved indications or clinical trials reported for this compound.

Other names

4-{[(4-cyanophenyl)(4H-1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamate4-{[(4-cyanphenyl)(1,2,4-triazol-4-yl)amino]methyl}phenyl sulfamateSulfamic acid, 4-[[(4-cyanophenyl)-4H-1,2,4-triazol-4-ylamino]methyl]phenyl ester