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Drug intelligence / Profile preview
4-[18F]Fluoroglutamic acid
- Development stage
- Phase 1
- Lead developer
- Bayer
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Positron Emitters → Radiopharmaceuticals, Small Molecules
- Administration
- Intravenous
01
Overview
**4-[18F]Fluoroglutamic acid (BAY85-8050)** is a radiolabeled amino acid derivative developed as a positron emission tomography (PET) imaging agent. It consists of fluorine-18 conjugated to L-glutamic acid, which leverages tumor-specific uptake due to high glutaminolytic metabolism in certain tumors. Upon intravenous administration, it accumulates in tumor cells, enabling imaging and assessment using PET. The compound is intended for oncology imaging, specifically for detecting and assessing neoplasms via PET scans. The developer is Bayer.
- Other names
- 2-amino-4-(18F)-fluoropentanedioic acid4-fluoroglutamic acidgamma-fluoroglutamic acid4-fluoroglutamic acid (L)-isomerL-glutamic acid 4-(fluoro-18F)-
02
Targets
EAAT3 (Excitatory amino acid transporter 3)SLC7A11 (Cystine-Glutamate Antiporter)OATP (Organic anion transporting polypeptides)
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