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4-[18F]Fluoroglutamic acid

Development stage: Phase 1
Lead developer: Bayer
Modality: Small Molecules, Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
Administration: Intravenous

Overview

**4-[18F]Fluoroglutamic acid (BAY85-8050)** is a radiolabeled amino acid derivative developed as a positron emission tomography (PET) imaging agent. It consists of fluorine-18 conjugated to L-glutamic acid, which leverages tumor-specific uptake due to high glutaminolytic metabolism in certain tumors. Upon intravenous administration, it accumulates in tumor cells, enabling imaging and assessment using PET. The compound is intended for oncology imaging, specifically for detecting and assessing neoplasms via PET scans. The developer is Bayer.

Other names: 2-amino-4-(18F)-fluoropentanedioic acid4-fluoroglutamic acidgamma-fluoroglutamic acid4-fluoroglutamic acid (L)-isomerL-glutamic acid 4-(fluoro-18F)-

Targets

EAAT3 (Excitatory amino acid transporter 3)SLC7A11 (Cystine-Glutamate Antiporter)

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