4-[3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl]pyrimidin-2-amine

**4-[3-(4-chlorophenyl)-2,1-benzisoxazol–5–yl]pyrimidin–2–amine** is a synthetic small molecule that acts as an experimental inhibitor of serine/threonine-protein kinase pim‑1 (PIM‑1). It belongs to the class of aminopyrimidines and derivatives. The compound has been studied for its ability to inhibit PIM‑1 kinase activity with a reported Ki of approximately 91 nM. PIM‑1 is implicated in cell survival and proliferation pathways and is considered a potential target in oncology research. This compound has not been approved for clinical use and remains at the experimental stage[1][2].

Other names

4-(3-(4-chlorophenyl)-2,1-benzisoxazol-5-yl)pyrimidin-2-amine4-[3-(4-chlorophenyl)-2,1-benzoxazol-5-yl]pyrimidin-2-amineDB08707DB-08707DB 08707477845–12–8