4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol

4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene‑1,3‑diol is a synthetic small molecule belonging to the benzisoxazole class of organic compounds. It acts as a potent inhibitor of heat shock protein HSP90-alpha (Hsp90), a molecular chaperone involved in the activation and stabilization of various signaling proteins. Inhibition of Hsp90 disrupts its chaperone function and can lead to degradation of client proteins important for cancer cell survival. This compound was identified through structure-based drug design and has demonstrated nanomolar inhibitory activity against Hsp90 in biochemical assays[1][5][7]. Its primary research application is as an experimental tool compound for studying Hsp90 inhibition.

Other names

4-bromo-6-(6-hydroxybenzo[d]isoxazol-3-yl)benzene-1,3-diol4-Brom-6-(6-hydroxy-benzo[d]isoxazol-3-yl)-benzene-1,3-diol