4-oxo-4,5-dihydro-1,2,5-thiadiazole-3-carboxylic acid

4-Oxo‑4,5‑dihydro‑1,2,5‑thiadiazole‑3-carboxylic acid is a small molecule belonging to the thiadiazole family. It features a five-membered heterocyclic ring containing two nitrogen atoms and one sulfur atom. The compound has been studied primarily as an experimental inhibitor of L-lactate dehydrogenase (LDH), particularly the A and B chains (LDHA and LDHB). Its structure includes both carboxylic acid and oxo functional groups. While it has shown potential for biochemical applications—especially as an LDH inhibitor—there are no approved medical indications or clinical trials reported for this compound. It is mainly used in research settings to probe metabolic enzyme function or as a synthetic intermediate in medicinal chemistry[1][2][6].

Other names

4-hydroxy-1,2,5-thiadiazole-3-carboxylic acid45654-48-6841–924–1GBD1,2,5-Thiadiazole-TDA1